Brian Zid

2018 Hellman Fellow

Assistant Professor, Chemistry & Biochemistry
UC San Diego

Project Title: The Role of RNA/Protein Mislocalization During Aging

Project Description: During aging many proteins condense into misfolded aggregates. This detrimental aggregation appears to be linked to a number of neurodegenerative diseases including Alzheimer’s, Parkinsons, and Lou Gehrig’s disease. One class of proteins that appear to be especially sensitive to aggregation are RNA-binding proteins. We have found using the model system yeast, that similar to human neurodegeneration a subclass of RNA-binding proteins aggregate during yeast aging, and that this is detrimental to the cell. Funding from the Hellman Fellows Fund will allow my lab to explore why these aggregates form and mechanistically how they are detrimental to the cell. This basic research in yeast may give insight into how protein aggregation affects cellular physiology during aging in higher eukaryotes