Zeba Wunderlich

2017 Hellman Fellow

zeba$uci.edu

Assistant Professor, Developmental and Cell Biology
UC Irvine

Project Title: Translating noisy signals into predictable developmental patterning

Regulatory DNA encodes the gene regulatory networks that are required for virtually every process in an animal, from development to immunity. The Wunderlich lab is interested in understanding how a gene regulatory network’s tasks influence its architecture, robustness, and evolvability. To probe these questions, we use two model systems: the Drosophila early embryonic patterning system and the Drosophila innate immune response. In both systems, we pair imaging-based and genomic measurements of gene expression with statistical and physically-based computational models to explore questions of gene regulatory network function. We exploit naturally-occuring sequence variation between individuals and species as a tool to measure how changes in regulatory DNA affect transcriptional regulation.

Lab website: http://wunderlichlab.org